BioCentury
ARTICLE | Targets & Mechanisms

Fine-tuning mGluRs

January 5, 2012 8:00 AM UTC

Studies by two American teams have converged on a family of metabotropic glutamate receptors as players in attention deficit hyperactivity disorder and autism spectrum disorder.1,2 The findings build an argument for agonizing the receptors in patients with either ADHD or a form of ASD associated with tuberous sclerosis complex and antagonizing the targets to treat a different form of ASD associated with fragile X syndrome.

Determining which patients could benefit from which approach will require new diagnostics...