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Targeting cardiolipin in pneumonia

U.S. researchers have developed a new way for treating pneumonia resistant to standard first-line therapy with broad-spectrum antibiotics. Instead of attacking the bacteria, the researchers designed a peptide that binds cardiolipin, a host-generated lipid involved in lung tissue inflammation and injury.1

Cardiolipin is found almost exclusively in the membranes of mitochondria, in which it helps maintain membrane architecture and provides stability for enzymes involved

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