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Overcoming C. differences

It has beenknown for some timethat the pathogenesis of Clostridium difficile depends on a pair of toxic proteins secreted by the bacterium. But it has been less clear which of the two toxins-toxin A or toxin B-represents a better therapeutic target. Now, a report by British researchers makes a case that the toxins should be jointly targeted.1

The findings, which were published in Nature, support the dual toxin-targeting strategies behind mAb-based therapies being pursued by Merck & Co. Inc.,which has MK-3415A, a coformulation of mAbs against toxins A and B, and by Progenics Pharmaceuticals Inc., which has preclinical

mAbs targeting both toxins.

Toxins A and B are large proteins that penetrate into

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