Inhibiting inflammation in epilepsy

A team of Italian and Dutch academicshas identified two proinflammatory targets in the brain-toll-like receptor 4 (TLR4) and high mobility group box 1 (HMGB1)-that help drive epileptic seizures in mice.¹ HMGBiotech s.r.l.,

which is associated with one of the researchers, has already begun developing brain-penetrant HMGB1 antagonists. Another Italian biotech,Bio3 Research s.r.l., is now evaluating the potential to use its cardiovascular HMGB1 inhibitor in epilepsy...