Autoimmunity Gets Mincle and Dimed

Researchers at the RIKEN Research Center for Allergy and Immunology have identified MINCLE as a receptor that triggers neutrophil recruitment and secretion of proinflammatory cytokines in response to necrotic cells derived from injured tissue.1 Companies next want to see data in animals demonstrating the link between the receptor and autoimmune diseases. If the mechanistic link is confirmed, the receptor could be a more specific and selective target than the targets of currently marketed drugs.

C-type lectin domain family 4, member e (MINCLE) falls into the class of c-type lectin receptors,

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