BioCentury
ARTICLE | Targets & Mechanisms

Reining in Renin

June 26, 2008 7:00 AM UTC

Although antihypertensives have become the standard of care in diabetic nephropathy, the mechanistic link between hyperglycemia and blood pressure, as well as between hyperglycemia and potential downstream renal damage, has remained elusive.1

A paper published in The Journal of Clinical Investigation has now identified a G protein-coupled receptor (GPCR) in the kidneys that may link diabetic hyperglycemia to hypertension. Antagonizing the receptor could thus be a new strategy to treat or prevent nephropathy in diabetes patients...