Secretoneurin: twice is not enough

The graveyard of stroke compounds has been filled by both thrombolytics, which restore blood flow, and neuroprotectants, which protect brain tissue from infarction. Recently, researchers reported in The Journal of Clinical Investigation that the endogenous peptide secretoneurin has two potential roles in stroke-neuroprotection and recruitment of stem cells to the brain to potentially help replace damaged tissue.¹

Despite these intriguing dual roles, clinicians and biotech companies focused on stroke therapies are not holding out much hope for secretoneurin, for reasons specific to the indication and the target itself...