Scots aggregate a ligase platform

For the past three years, Scottish Enterprisehas been working with multiple international academic and commercial labs to investigate therapeutic targets that were regarded as too challenging by many drug development companies. Now, the Scottish government's economic development agency has lifted the curtain on its most advanced life science program-small molecule modulators of E3 ubiquitin ligase proteins.

The ubiquitin-proteasome system contains the cell's chief machinery for breaking down proteins and is dysfunctional in a variety of cancers, including lymphomas and prostate, bladder and breast cancer...