7:20 AM
Jul 12, 2018
 |  BC Innovations  |  Emerging Company Profile

Gene control goals

How Camp4’s computational platform identifies druggable targets that control disease genes

By mapping all of the signaling pathways and transcription factors that control the expression of every gene in a cell type of interest, Camp4 Therapeutics Corp. is betting its machine learning-based platform will be able to identify druggable targets that can control gene expression without the need for physical target screening.

According to CEO Josh Mandel-Brehm, many genetic diseases could be treated by adjusting the expression levels of the mutated gene or a compensatory one. But finding the right target to achieve the desired gene expression change can be tricky due to the complex and dynamic nature of transcriptional regulation.

Camp4’s 4-D Gene Circuitry Platform integrates experimental data generated in house from functional genomic sequencing assays, transcriptome chromatin profiling and other methods to create a computational model of all of the different combinations of signaling...

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