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8:53 AM, Aug 15, 2018  |  BC Innovations | Emerging Company Profile

Breaking bad biofilms

Synspira LLC is developing glycopolymers against pulmonary disorders by targeting three mechanisms that exacerbate pulmonary decline: bacteria themselves, the mucus and biofilms that protect them and inflammation that leads to lasting tissue damage. Synspira in-licensed its...
11:40 AM, Aug 08, 2018  |  BC Innovations | Emerging Company Profile

Catching antibodies with polymers

Polyneuron Pharmaceuticals AG's glycopolymers act as decoys for the autoantibodies that drive autoimmune diseases, such as anti-MAG neuropathy, and are designed to be more effective and safer than other therapies. Polyneuron's Antibody-Catch platform generates glycopolymers that...
12:29 PM, Aug 01, 2018  |  BC Innovations | Emerging Company Profile

Connecting the DotBodies

Cancer play DotBio Pte. Ltd. launched this week with a screening platform to discover and develop products based on humanized domain antibodies that could be more stable and easier to manufacture than other domain antibodies. DotBio...
12:06 PM, Jul 26, 2018  |  BC Innovations | Emerging Company Profile

The universe in an exosome

Versatope Therapeutics Inc. is using exosomes from commensal E. coli as the backbone of a universal influenza vaccine that should be cheaper and easier to manufacture than other vesicle-based vaccines. The company’s technology was developed by...
1:26 PM, Jul 18, 2018  |  BC Innovations | Emerging Company Profile

Ministring theory in practice

Mediphage Bioceuticals Inc.’s ministrings have safety, manufacturing and other advantages that could give conventional plasmids and related vectors a run for their money in the gene therapy space. The newco’s ministrings are linear DNAs with covalently...
7:20 AM, Jul 12, 2018  |  BC Innovations | Emerging Company Profile

Gene control goals

By mapping all of the signaling pathways and transcription factors that control the expression of every gene in a cell type of interest, Camp4 Therapeutics Corp. is betting its machine learning-based platform will be able...
12:52 PM, Jun 28, 2018  |  BC Innovations | Emerging Company Profile

Stress relief for neurons

Aquinnah Pharmaceuticals is developing disease-modifying therapies for amyotrophic lateral sclerosis and Alzheimer’s disease by inhibiting the formation of stress granules that promote protein aggregation in neurons. Stress granules are protein-RNA complexes assembled by RNA-binding proteins that...
11:29 AM, Jun 21, 2018  |  BC Innovations | Emerging Company Profile

Getting past PTSD

Neurovation Labs Inc. is developing a GRIA1-targeting tracer and a small molecule therapy that could provide an objective diagnosis of PTSD and treat the underlying disease instead of just its symptoms. Post-traumatic stress disorder (PTSD) is...
2:50 PM, Jun 14, 2018  |  BC Innovations | Emerging Company Profile

Beaming about base changes

Beam Therapeutics launched with a CRISPR-guided base editor platform that could introduce more precise point mutations than other gene editing technologies without the risk of off-target cuts. Founded by CRISPR veterans David Liu of Harvard University,...
12:45 PM, Jun 07, 2018  |  BC Innovations | Emerging Company Profile

Radio fusion

Fusion Pharmaceuticals Inc. is improving the safety of radiopharmaceuticals for cancer by using a proprietary linker to label antibodies with the radioisotope actinium-225. While the newco remains tight-lipped about the linker’s design, SVP of Business Development...

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