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    E.g., 2018-09-22
    E.g., 2018-09-22

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9064 items
9:14 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma Patient sample and mouse studies suggest inhibiting USP7 could help treat metastases of melanoma. In 114 melanoma patients, high primary tumor levels of USP7 correlated with poor survival, and in eight xenograft mouse...
9:13 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Mouse and rat studies suggest inhibiting PANX1 or its activator P2RX7 in spinal microglia, or an antibody-drug conjugate (ADC) targeting the microglia, could help treat joint pain. In spinal cord samples from a rat...
9:13 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer In vitro and cell culture studies identified a dual CDK12/CDK13 inhibitor that could help treat breast cancer. Screening of a small molecule library and in vitro enzyme activity assays followed by structure-based optimization...
9:12 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample and mouse studies suggest inhibiting TRPS1 could help treat breast cancer. In tumor samples from 1,247 breast cancer patients, levels of TRPS1 were higher than in adjacent normal tissue, and high...
9:12 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Hepatitis C virus (HCV) In vitro, cell culture, rat and dog studies identified a CYPA inhibitor that could help treat HCV. Chemical synthesis of analogs of the natural product sanglifehrin A and in vitro binding...
9:12 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Inflammation; endocrine/metabolic

INDICATION: Inflammation; diabetes In vitro and mouse studies identified a selective SGMS2 inhibitor that could help treat chronic inflammation and Type II diabetes. Chemical synthesis of benzoisoxazole analogs and in vitro enzyme activity assays yielded a...
9:11 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Schizophrenia In vitro and mouse studies identified a brain-penetrating GlyT1 inhibitor that could help treat schizophrenia. Chemical synthesis of 3,4-disubstituted pyrrolidine sulfonamides and in vitro binding assays yielded a compound that bound GlyT1 with...
9:10 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Autism Mouse studies suggest optogenetically activating or agonizing 5-HT1B receptors on neurons projecting from the dorsal raphe to the nucleus accumbens could help treat autism spectrum disorders (ASDs) caused by a deletion at the 16p11.2...
9:10 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer; lung cancer Cell culture studies identified a triple KRAS/NRAS/HRAS inhibitor that could help treat KRAS-mutant colorectal cancer and NRAS-mutant non-small cell lung cancer (NSCLC). Screening of a small molecule library, structure-based optimization of...
9:10 AM, Aug 16, 2018  |  BC Innovations | Distillery Therapeutics

Hepatic

INDICATION: Hepatic Patient sample and mouse studies suggest inhibiting CDK4 could help treat age-associated hepatic steatosis. In liver samples from 12 non-alcoholic fatty liver disease (NAFLD) patients with hepatic steatosis and 17 non-alcoholic steatohepatitis (NASH) patients,...

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