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8837 items
3:48 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Non-small cell lung cancer (NSCLC); lymphoma Cell culture studies suggest conjugates of pomalidomide and ALK inhibitors could help treat NSCLC and anaplastic large cell lymphoma (ALCL). The conjugates consist of the thalidomide analog Pomalyst...
3:47 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting ZRANB1 could help treat breast cancer. In breast cancer patients, high tumor levels of ZRANB1 were associated with poor overall survival. In 10...
3:47 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse studies suggest normalizing the ratio of tau four-repeat (4R) to tau 3R transcript levels could help treat tauopathies. In a mouse model of tauopathy, a lentiviral vector encoding a pre-trans-splicing molecule that yields...
3:46 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Cell culture studies identified DNA-binding rhodium complexes that could help treat colorectal cancer harboring mutations in the DNA mismatch repair pathway. Chemical synthesis and in vitro binding assays of rhodium complexes, each containing...
3:46 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular

INDICATION: Hypertension Patient sample and rat studies suggest inhibiting CD126 could help treat pulmonary arterial hypertension (PAH). In lung samples from lung transplant patients with idiopathic PAH or in a rat model of PAH, levels...
3:46 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Pneumonia Mouse studies suggest inhibiting IP6K1 could help treat bacterial pneumonia. In mouse models of E. coli- or Staphylococcus aureus-induced pneumonia, systemic IP6K1 knockout decreased bacterial burden, edema and neutrophil infiltration in the lung, and...
3:45 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Musculoskeletal

INDICATION: Osteoporosis; musculoskeletal Mouse studies suggest inhibiting S1P lyase could help treat osteoporosis and osteopenia. In an osteoprotegerin (OPG)-knockout mouse model of osteoporosis, a tool compound S1P lyase inhibitor increased trabecular bone volume density and a...
3:45 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Viral infection; Chikungunya virus; influenza virus; rotavirus Cell culture studies suggest inhibiting STAG2 could help treat RNA viral infections. Screening of a CRISPR single-guide (sgRNA) library in HeLa cells challenged with a bovine rotavirus strain...
3:45 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Cell culture and mouse studies suggest CAR T cells targeting GD2 could help treat diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas harboring the H3.3A K27M mutation. In co-culture with patient-derived...
3:44 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Hematology

INDICATION: Myeloproliferative disorder Patient sample and mouse studies suggest inhibiting Hsp27 could help treat myelofibrosis (MF). In serum samples and circulating hematopoietic progenitor cells from patients with myeloproliferative neoplasm (MPN)-associated MF, levels of Hsp27 were higher...

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