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8922 items
3:43 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Neurology Mouse studies suggest CSF1R inhibitors could help treat age-related neurodegeneration. In a mouse model of age-related neurodegeneration, a tool compound CSF1R inhibitor decreased markers of age-related neuropathy including the numbers of thinly myelinated...
3:43 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies suggest AIBP could help treat neuropathic pain. In mouse models of lipopolysaccharide (LPS)- and chemical-induced neuropathic pain, intrathecal AIBP decreased mechanical allodynia compared with vehicle. Also in the model of chemical-induced neuropathic...
3:43 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer An RNA-targeting small molecule that cleaves miR-96 could help treat triple-negative breast cancer (TNBC). The compound consists of a short poly(A) oligionucleotide linked to a small molecule that selectively binds the oncogenic precursor...
3:42 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Trypanosome In vitro studies identified tetrahydrophthalazinone-based inhibitors of T. brucei PDEB1 that could help treat African trypanosomiasis. Chemical synthesis and in vitro activity and cell division assays of tetrahydrophthalazinone analogs yielded two compounds that...
3:41 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Cancer; ophthalmic disease

INDICATION: Pancreatic cancer; age-related macular degeneration (AMD) Cell culture and mouse studies suggest a SEMA3A-based fusion protein could help treat metastatic pancreatic cancer and AMD. The fusion protein consisted of the sema and plexin-semaphorin-integrin domains of...
3:41 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Renal

INDICATION: Renal damage Patient sample, cell culture and mouse studies suggest MIF or its receptor CD74 could help treat ischemia/reperfusion-associated acute kidney injury (AKI). In serum samples from 60 cardiac bypass surgery patients who experienced surgery-related...
3:41 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Spinal cord injury (SCI) Pig studies suggest allogeneic neural progenitor cells (NPCs) derived from induced pluripotent stem (iPS) cells could help treat SCI. In a pig model of SCI, intra-lumbar spinal cord transplantation of allogeneic...
3:41 PM, Jun 05, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Malaria Mouse studies identified imidazopyridine-based compounds that could help treat malaria. Screening of a small molecule library in parasite culture followed by optimization of an imidazopyridine-based screening hit yielded two compounds that inhibited Plasmodium...
11:57 AM, May 30, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Epilepsy Studies in mice suggest Akkermansia muciniphila, Parabacteroides merdae and Parabacteroides distasonis could help treat epilepsy. In a mouse model of epilepsy, a ketogenic diet increased colonic populations of A. muciniphila and Parabacteroides spp.,...
11:57 AM, May 30, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer In vitro, cell culture and mouse studies suggest inhibiting the DNAJ/Hsp70 chaperone axis could help treat castration-resistant prostate cancer (CRPC). Screening of a library of chalcone analogs and testing in cell-based signaling assays...

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