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8648 items
4:53 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Alzheimer's disease (AD) Mouse studies identified a prodrug of a TrkB agonist that could help treat AD. Chemical synthesis and testing in mouse-based PK assays of prodrugs of a 7,8-dihydroxyflavone-based TrkB agonist yielded a carbamate-functionalized...
4:52 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Stroke Patient sample and mouse studies suggest inhibiting miR-143 or promoting expression of its inhibitor DLGAP4’s circular RNA (circRNA) could help treat stroke. In serum samples from patients, levels of miR-143 were higher and levels...
4:51 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Hematology

INDICATION: Bleeding Patient sample and mouse studies suggest HIF1A stabilizers could help treat heavy menstrual bleeding. In endometrial samples from patients, levels of HIF1A were lower than in patients with normal menstrual bleeding. In a mouse...
4:51 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Pancreatic cancer; breast cancer; lung cancer In vitro, cell culture and mouse studies identified a naphthalene diimide-based stabilizer of G-quadruplex DNA that could help treat pancreatic ductal adenocarcinoma (PDAC), breast and lung cancers. Chemical synthesis,...
4:39 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Bone cancer; colorectal cancer Cell culture and mouse studies suggest inhibiting SIRT5-mediated desuccinylation of SHMT2 could help treat osteosarcoma and colorectal cancer. In a human osteosarcoma cell line, knockout of SIRT5 increased levels of reactive...
4:39 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Pancreatic cancer Mouse studies suggest mesenchymal stem cell (MSC)-derived vesicles loaded with a CXCR3 inhibitor could help treat pancreatic cancer. The vesicles are derived via sonication from the membranes of tumor-targeting primary human bone marrow...
4:39 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer; breast cancer; colorectal cancer Cell culture and mouse studies identified an indole-quinoline-based dual PIP4K2A/PIP4K2C inhibitor that could help treat Ras-driven glioma, breast cancer and colorectal cancer. Screening of a small molecule library in...
4:39 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Acute lymphoblastic leukemia (ALL); multiple myeloma (MM) In vitro and cell culture studies suggest stapled peptide inhibitors of MCL1 could help treat ALL and MM. Modification of previously identified peptide-based inhibitors of MCL1 with hydrocarbon...
2:22 PM, Jan 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Worm and mouse studies suggest promoting NAD+ synthesis could help treat AD. In a worm model of AD, the NAD+ precursor nicotinamide riboside or the PARP inhibitor Lynparza olaparib, which blocks...
2:21 PM, Jan 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture studies identified a theophylline-based NUDT5 inhibitor that could help treat breast cancer. High throughput screening of small molecule libraries, testing in vitro and optimization of a screening hit yielded a theophylline...

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