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    E.g., 2018-06-24

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8837 items
4:29 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Enterovirus Cell culture and mouse studies suggest inhibiting KREMEN1 alone or in combination with KREMEN2 could help treat coxsackie viral infections. An insertional mutagenesis screen in a human cell line challenged with the coxsackie...
4:29 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Dermatology

INDICATION: Itch Mouse studies suggest agonizing KOR could help treat itch. In a mouse model of acute itch, a tool compound KOR agonist decreased scratching behavior compared with vehicle. In mouse models of chronic itch, dry...
4:29 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies identified a TF-binding immunoconjugate that could help treat triple-negative breast cancer (TNBC). The immunoconjugate consists of a factor VII peptide light chain fused to IgG1 that binds TF,...
4:28 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Infectious

INDICATION: Gram-negative bacterial infection; Gram-positive bacterial infection; fungal infection Cell culture and mouse studies suggest peptides derived from a guava antimicrobial peptide (AMP) could help treat bacterial and fungal infections. Screening of 15 synthetic peptide analogs...
4:28 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Musculoskeletal

INDICATION: Bone repair; tissue damage Patient sample and mouse studies suggest HMGB1 could treat bone fracture and muscle injury. In plasma samples from patients with fractured femurs, levels of HMGB1 were higher than in samples from...
4:28 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Addiction Rat studies identified a carboxamide-based 5-HT2C receptor positive allosteric modulator (PAM) that could help treat cocaine addiction. Chemical synthesis and in vitro activity testing of analogs of the 5-HT2C receptor PAM lincomycin yielded...
4:27 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Non-small cell lung cancer (NSCLC) Studies in mice suggest dual inhibition of IRS1 and IRS2 could help treat KRAS-mutant NSCLC. In a mouse model of KRAS-mutant NSCLC, lung-specific dual knockout of IRS1 and IRS2 increased...
4:27 PM, May 01, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Inflammatory bowel disease (IBD) Mouse studies identified a peptide-based GLP-2R activator that could help treat IBD. Chemical synthesis and testing in a cell-based activity assay of GLP-2-based stapled peptides yielded a peptide that activated GLP-2R...
3:50 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Cell culture studies suggest CAR T cell therapies targeting CEACAM5 could help treat neuroendocrine prostate cancer. Bioinformatics analysis of 7,555 human cell surface proteins, and transcriptomic and proteomic analyses of eight human prostate...
3:49 PM, Apr 24, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Esophageal cancer Patient sample and cell culture studies suggest inhibiting TSPAN15 could help treat esophageal squamous cell carcinoma. In 266 patients, high tumor expression of TSPAN15 was associated with metastasis, disease severity and poor...

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