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8648 items
9:03 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Mouse studies suggest IL-33 could help treat MS. In brain samples from the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, mast cell levels of IL-33 were lower in female mice than...
9:02 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Tuberculosis Non-human primate studies suggest a vaccine based on cytomegalovirus (CMV) expressing six M. tuberculosis antigens could help prevent tuberculosis (TB). The vaccine consists of six bacterial antigens -- M. tuberculosis fbpA, esxA, vapB47, Rv2626,...
9:02 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample and mouse studies suggest promoting IGFBP3 expression could help treat MYCN-driven neuroblastoma. In five MYCN-driven neuroblastoma cell lines, IGFBP3 encoded by a plasmid vector decreased viability compared with GFP. In a...
9:02 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Autism Mouse studies suggest IGF-2 could help treat autism. In a mouse model of autism, a single subcutaneous 30 μg/kg dose of IGF-2 decreased social interaction deficits, long-term non-aversive and aversive memory deficits and stereotyped...
8:47 AM, Feb 01, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Patient sample and mouse studies suggest agonizing ABCA1 could help treat MS. In the experimental autoimmune encephalomyelitis (EAE) mouse model of MS, a tool compound ABCA1 agonist increased walking ability and rotarod...
2:11 PM, Jan 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Gastric cancer Patient sample, cell culture and mouse studies suggest inhibiting IRF3 could help treat gastric cancer. In patient samples, high levels of IRF3 tumor RNA and protein correlated with tumor size and poor survival....
2:10 PM, Jan 31, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Bacterial infection Cell culture, patient sample and mouse studies identified a CAMP-based antibacterial peptide that could help treat multidrug-resistant (MDR) bacterial infections. Chemical synthesis and bacterial viability assays of CAMP analogs yielded a peptide that...
2:10 PM, Jan 31, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Parkinson's disease (PD) Patient samples and mouse studies suggest promoting clearance of CDKN2A-positive senescent cells could help treat PD. In postmortem substantia nigra tissue samples from patients, levels of the cellular senescence cell marker CDKN2A...
9:01 AM, Jan 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Mouse studies suggest combining CD40 agonists and CSF1R inhibitors could help treat colorectal cancer. In two mouse models of colon cancer, an anti-CD40 agonist antibody plus an anti-CSF1R antibody inhibitor decreased tumor...
4:53 PM, Jan 30, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Addiction Mouse studies suggest inhibiting G-CSF could help treat cocaine addiction. In a mouse conditioned place preference (CPP) model of cocaine reward, nucleus accumbens injection of an anti-G-CSF antibody decreased cocaine reward-seeking behavior compared with...

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