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8922 items
11:23 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Acute lymphoblastic leukemia (ALL); ovarian cancer; solid tumors Mouse studies suggest IL-18-secreting CAR T cells could help treat ALL, thymoma and ovarian cancer. In a xenograft mouse model of ALL, CD19-targeting CAR T cells engineered...
11:22 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Candida HEK cells engineered to synthesize and secrete bacterial AI-2 could help treat candidiasis. The cells are generated by transfecting HEK cells with two constructs: a sensor unit, based on formyl peptide receptor 1 (FPR1),...
11:21 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer In vitro and cell culture studies identified a quindoline-based stabilizer of the NRAS mRNA G-quadruplex region that could help treat cancer. Chemical synthesis and in vitro testing in binding and enzyme activity assays of...
11:21 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lung cancer, sarcoma Cell culture studies suggest inhibiting IFT88 or SCLT1 could help treat kinase inhibitor-resistant lung cancer and rhabdomyosarcoma. In a human EGFR inhibitor-resistant non-small cell lung cancer (NSCLC) cell line, the EGFR inhibitor...
11:20 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Liver cancer Mouse studies suggest primary bile acids or depletion of gut microbiota could help treat liver tumors by increasing hepatic natural killer T (NKT) cell infiltration. In mouse models of liver cancer and thymoma...
11:19 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Solid tumors; pancreatic cancer; colorectal cancer; breast cancer; lung cancer; ovarian cancer Patient sample and mouse studies suggest anti-ANTXR1 antibody-drug conjugates (ADCs) could help treat solid tumors. In tissue samples from esophageal, kidney, uterine, colorectal,...
11:19 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Viral infection Mouse studies suggest ZFP36 inhibitors could help treat acute lymphocytic choriomeningitis virus (LCMV) infection. In a mouse model of acute LCMV infection, systemic ZFP36 knockout increased the number of LCMV-specific CD4+ T cells...
11:19 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: HIV/AIDS In vitro and cell culture studies identified an allophenylnorstatine-tetrahydrofuranylglycine conjugate-based inhibitor of HIV protease that could help treat protease inhibitor-resistant HIV infection. Chemical synthesis and in vitro activity assays of allophenylnorstatine-tetrahydrofuranylglycine conjugate analogs yielded...
11:18 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Retinitis; ophthalmic In vitro, mouse and cell culture studies identified a mutant RHO-stabilizing compound that could help treat retinal degeneration and autosomal dominant retinitis pigmentosa (adRP). High throughput screening and testing in a ligand-binding assay...
11:18 AM, Jun 13, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular

INDICATION: Heart failure Patient sample and cell culture studies suggest inhibiting microtubule detyrosination or promoting expression of tubulin tyrosine ligase (TTL) could help treat heart failure. In left ventricular tissue samples from patients, the density of...

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