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    E.g., 2018-09-23
    E.g., 2018-09-23

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9064 items
10:50 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Dermatology

INDICATION: Wounds Cell culture and mouse studies suggest overexpressing SOX2 could promote cutaneous wound healing. In primary human epidermal keratinocytes, SOX2 overexpression increased migration compared with normal SOX2 expression. In a mouse model of cutaneous wound...
10:50 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Malaria In vitro, cell culture and mouse studies identified asparagine ethylenediamine-based inhibitors of Plasmodium falciparum proteasome subunit β type 5 that could help treat malarial infection. Screening of a library of tool compound proteasome...
10:50 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer; breast cancer Cell culture and mouse studies identified an isoflavanone-based compound that could help treat metastatic prostate and breast cancers. Screening of flavinoids in cell-based activity assays and chemical synthesis of hits...
8:55 AM, Aug 23, 2018  |  BC Innovations | Distillery Therapeutics

Other

INDICATION: Genetic disorders Cell culture and mouse studies identified a covalent STING inhibitor that could help treat Aicardi-Goutières syndrome, an inflammatory disorder is caused by mutations in one of seven genes, including TREX1. Screening of a...
8:55 AM, Aug 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Cell and rat studies identified three TrkA/TrkB/TrkC inhibitors that could help treat pain. Screening of a small molecule library in cell-based activity assays yielded three analogs of a core scaffold -- a piperidine-pyridine compound,...
8:54 AM, Aug 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Neuroendocrine tumors Cell culture and mouse studies suggest a nanoparticle formulation of withaferin A could help treat neuroblastoma. In 12 human neuroblastoma cell lines, withaferin A increased cell death compared with etoposide or cisplatin. In...
8:54 AM, Aug 23, 2018  |  BC Innovations | Distillery Therapeutics

Infectious

INDICATION: HIV/AIDS Primate studies suggest combining CD4 mimetics with HIV gp120-based vaccines could help prevent HIV. In macaques challenged with simian human immunodeficiency virus (SHIV) immunized with HIV gp120 variants, a CD4 mimetic prevented infection in...
8:53 AM, Aug 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Neurology Patient sample and rabbit studies suggest estradiol could help treat neurobehavioral disorders associated with defects in interneuron development resulting from preterm birth. In postmortem brain samples from preterm to full-term infants (20-40 gestational weeks),...
8:53 AM, Aug 23, 2018  |  BC Innovations | Distillery Therapeutics

Gastrointestinal

INDICATION: Gastrointestinal Cell culture and mouse studies suggest deoxycholate-mediated PGE2 inhibition or agonism of FXR could help treat colonic injury. In a mouse model of colonic mucosal biopsy injury, PGE2 levels were higher during the barrier...
8:53 AM, Aug 23, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Malaria Cell culture and mouse studies identified an inhibitor of P. falciparum proteasome subunit β type 2 and proteasome subunit β type 5 that could help treat malaria. Chemical synthesis and testing of vinyl sulfone...

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