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    E.g., 2018-06-24

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8837 items
1:01 PM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Renal; cardiovascular; hepatic

INDICATION: Renal failure; heart failure; liver failure Mouse studies suggest inhibiting YY1 or its co-repressor FKBP12 could help treat chronic renal, heart and liver failure. In a mouse model of urethral obstruction-induced chronic renal failure, a...
8:24 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Patient sample, cell culture and chicken embryo studies suggest inhibiting FZD8 could help treat prostate cancer. In patient samples, levels of FZD8 were higher in tumors than in adjacent normal prostate tissue. In...
8:22 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Dermatology

INDICATION: Itch Mouse studies suggest activating Merkel cells could help treat itch. In a mouse model of age-related dry skin-induced itch, numbers of epidermal Merkel cells were lower than in normal mice. Also in the model,...
8:22 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample and cell culture studies suggest inhibiting BARD1, BRCA1, CDK1 or CKD12 could help treat tamoxifen-resistant breast cancer. In tumor tissue from 27 recurrent breast cancer patients whose tumors became resistant...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Musculoskeletal

INDICATION: Muscular dystrophy Mouse studies suggest that COX-2 inhibition could help treat Duchenne muscular dystrophy (DMD). In a mouse model of DMD, the COX-2 inhibitor Celebrex celecoxib decreased immune cell infiltration in tibialis anterior muscle and...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Otologic

INDICATION: Hearing loss Mouse studies suggest optogenetic therapy using an engineered mutant of the C. noctigama channelrhodopsin Chrimson could help treat age-related hearing loss. The mutant is a version of Chrimson engineered to inactivate quickly...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Gastrointestinal

INDICATION: Pancreatitis Mouse studies suggest PIEZO1 inhibition could help treat pancreatitis. In a mouse model of pressure-induced acute pancreatitis, pancreatic acinar cell-specific knockout of PIEZO1 or the PIEZO1 inhibitor AT-300 decreased histological disease scores and levels...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Hepatic

INDICATION: Liver disease Cell culture and mouse studies suggest liver-targeted TGFBR1 gene therapy could help treat Alagille syndrome, a genetic disease that affects the liver, bile duct and other tissues. In a mouse model of Alagille...
8:20 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer; breast cancer Cell culture and mouse studies identified an imidazoquinolinone-based ATM inhibitor that could help treat colorectal cancer or triple-negative breast cancer (TNBC) in combination with Camptosar irinotecan or Lynparza olaparib, respectively. In...
8:16 AM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular

INDICATION: Hypertension Cell culture and rat studies suggest nanoparticles loaded with cerivastatin could help treat pulmonary arterial hypertension (PAH) without the cytotoxicity of free cerivastatin. In a rat model of PAH, intratracheal administration of liposomes...

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