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    E.g., 2018-07-15

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8922 items
12:19 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample, cell culture and mouse studies suggest inhibiting AMPK could help treat glioma. In tumor samples from glioblastoma and low-grade glioma patients, levels of activated AMPK were higher than in brain tissue...
12:18 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Ebola Patient sample, mouse, guinea pig and ferret studies identified three broadly neutralizing antibodies (bNAbs) against Ebola virus glycoprotein that could help treat infections by multiple Ebolavirus species and strains. Screening of neutralizing antibodies isolated...
12:14 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Inflammation; neurology

INDICATION: Shock/trauma; stroke Mouse tissue and whole animal studies suggest inhibiting TRPV4 could help treat ischemic stroke-induced or traumatic brain injury (TBI)-induced brain edema. In a mouse brain slice model of oxygen-glucose deprivation-induced ischemia, systemic TRPV4...
12:13 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer; melanoma Cell culture and mouse studies suggest adoptive transfer of IL-15-cultured T cells could help treat B7-H6 tumor cell ligand-positive cancers. CD8+ T cells derived from human donor blood and cultured for 12 days...
12:13 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Malaria In vitro, cell culture and mouse studies identified naphthyridine-based inhibitors of P. falciparum PI4K that could help treat malaria. Chemical synthesis and testing in parasite growth assays of naphthyridine analogs yielded two compounds that...
12:05 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Diabetes Patient sample and mouse studies suggest inhibiting ANGPTL4 could help treat insulin resistance. In non-diabetic individuals, a loss-of-function mutation in ANGPTL4 was associated with low levels of fasting blood glucose and high insulin sensitivity....
12:04 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Gastrointestinal

INDICATION: Colitis Mouse studies suggest inhibiting IL-17F could help treat colitis. In a mouse model of chemical-induced colitis, systemic knockout of IL-17F decreased colitis severity compared with normal IL-17F expression, and a mAb against IL-17F decreased...
12:04 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Staphylococcus Cell culture studies suggest inhibiting adenosine kinase, DCK or SLC29A1 could help treat Staphylococcus aureus infection. Screening of a CRISPR single-guide RNA (sgRNA) library in a human lung lymphoblast cell line expressing CRISPR-associated protein...
12:04 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer; breast cancer Cell culture and mouse studies identified an azaindole-based compound that could help treat cancer. Chemical synthesis and testing of azaindole analogs in a human triple-negative breast cancer (TNBC) cell line yielded a...
12:04 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Hematology

INDICATION: Hematology Patient sample and mouse studies suggest gene editing of CD40L cDNA in autologous hematopoietic stem cells (HSCs) could help treat X-linked hyper-IgM syndrome (XHIM), which is caused by CD40L mutations. In patient-derived T cells,...

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