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    E.g., 2018-11-15
    E.g., 2018-11-15

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9185 items
1:27 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer; lung cancer Mouse studies suggest LPA could enhance the efficacy of chemotherapies and anti-PD-1 immunotherapies to treat brain and lung cancers. In a mouse model of glioma, LPA plus the generic chemotherapy temozolomide...
1:26 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Hepatic; renal

INDICATION: Liver disease; renal damage Cell culture and mouse studies suggest inhibiting ACMSD could help prevent non-alcoholic fatty liver disease (NAFLD) and acute kidney injury (AKI). In mouse primary hepatocytes, the ACMSD inhibitor TES-991 decreased...
1:26 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Addiction In vitro and mouse studies identified an illudalic acid-based PTPRD inhibitor that could help treat cocaine addiction. In a mouse model of cocaine addiction, heterozygous knockout of PTPRD decreased cocaine self-administration compared with normal...
1:26 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Blindness Mouse studies identified a LIF-based fusion protein that could help treat blindness. The fusion protein consists of human LIF fused to bacterial dihydrofolate reductase (DHFR), which is stabilized by the antibiotic Primsol trimethoprim. In...
1:25 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies suggest the combination of copper-palladium (Cu-Pd) nanoparticles, autophagy inhibitors and near-infrared (NIR) photothermal therapy could help treat breast cancer. In a mouse mammary carcinoma line and a human...
1:24 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer; infectious disease

INDICATION: Cancer; melanoma; cervical cancer; influenza virus Mouse and monkey studies suggest simvastatin could be used as an adjuvant to boost the efficacy of cancer and influenza vaccines. In mice, immunization with the antigen ovalbumin plus...
1:23 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Addiction Rat studies suggest M1 muscarinic receptor (CHRM1)-based chemogenetic inhibition of the prelimbic paraventricular thalamic nucleus pathway could help treat cocaine addiction. The system for chemogenetically inhibiting the pathway is initiated by bilateral injection into...
1:22 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Tuberculosis Cell culture and mouse studies suggest inhibiting M. tuberculosis mdh could help treat tuberculosis (TB). In M. tuberculosis cells engineered for doxycycline-inducible mdh depletion, doxycycline decreased colony formation compared with no treatment. In mice...
1:22 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies suggest inhibiting KDM4B alone or in combination with PI3K could help treat PTEN-deficient triple-negative breast cancer (TNBC). In a PTEN-deficient TNBC cell line, two siRNAs against KDM4B...
1:22 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Renal

INDICATION: Renal Patient sample and mouse studies suggest inhibiting DAB2 could help treat chronic kidney disease (CKD). A comparison of expression quantitative trait loci (eQTL) analyses of glomerular and tubular compartments from 151 CKD patients and...

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