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8648 items
8:27 AM, Feb 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample and mouse studies suggest inhibiting IL-1α or IL-6 could help treat HER2-positive breast cancer. In patient tumor samples, levels of IL-1α or IL-6 were associated with poor metastasis-free survival, and high...
8:25 AM, Feb 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lymphoma; breast cancer; colorectal cancer Mouse studies suggest intratumoral injection of a TLR9 agonist and an agonist antibody against OX40 could help treat lymphoma, breast cancer and colorectal cancer. In a mouse model of...
8:25 AM, Feb 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma Cell culture and mouse studies suggest a soluble form of SLAMF6 could enhance the effectiveness of T cell therapies for melanoma. In cultures of activated and expanded human tumor-infiltrating lymphocytes and mouse lymphocytes, a...
9:09 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Patient sample, cell culture and mouse studies suggest inhibiting HHAT could help treat colorectal cancer. In colorectal cancer cells from patients, siRNA targeting HHAT decreased spheroid formation and size compared with non-specific...
9:09 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Mouse studies suggest inhibiting PERK or IRE1 could help prevent embryonic microcephaly caused by Zika infection. In a mouse embryo model of Zika infection, tool compound PERK or IRE1 inhibitors decreased microcephaly compared...
9:08 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Endometrial cancer Cell culture and mouse studies suggest combining paclitaxel-loaded nanoparticles and the multikinase inhibitor Vargatef nintedanib could help treat p53-deficient endometrial cancer. In a p53-deficient human endometrial cancer cell line, paclitaxel-loaded nanoparticles plus...
9:08 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Mouse studies suggest inhibiting DLL4 could help treat diabetes. In a mouse model of diabetes, an anti-DLL4 antibody decreased hyperglycemia compared with a control antibody. In another mouse model of diabetes, the anti-DLL4 antibody...
9:08 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Cell culture and mouse studies suggest the selective serotonin reuptake inhibitor (SSRI) clomipramine could help treat MS. Screening a library of oral generic drugs that cross the blood-brain barrier (BBB) in a...
9:07 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Mouse studies suggest a protein nanoparticle vaccine based on M2e, HA1 and HA2 could help prevent influenza A virus infection. The vaccine consists of a mixture of nanoparticles, all having the same protein...
9:03 AM, Feb 06, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine / Metabolic

INDICATION: Diabetes Mouse studies suggest promoting FAM13A expression could help treat obesity-related diabetes. In a mouse model of high-fat diet-induced obesity, FAM13A levels in adipose tissue were higher than in mice fed a normal diet. Also...

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