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    E.g., 2018-06-24

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8837 items
11:09 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Musculoskeletal

INDICATION: Muscular atrophy Patient sample and mouse studies suggest inhibiting DKK3 could help treat sarcopenia. In vastus lateralis muscle samples from aged individuals with low body mass index (BMI), levels of DKK3 were higher than in...
11:09 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Cancer Cell culture studies suggest inhibiting KIF15 alone or in combination with KSP could help treat cancer. In HeLa cells, a tool compound KIF15 inhibitor decreased proliferation compared with no treatment, and the KIF15 inhibitor...
11:09 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Spinal cord injury (SCI) Cell culture and mouse studies suggest antagonizing OPRL1 alone or in combination with inhibiting its downstream effector RTN4R could help treat SCI. In primary mouse cortical neurons subjected to scrape injury,...
11:08 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Psoriasis Patient sample and mouse studies suggest inhibiting GLUT1 could help treat psoriasis. In patient samples, SLC2A1 levels were higher in skin lesions than in normal skin. In two mouse models of psoriasis, epidermal keratinocyte-specific...
11:07 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Arthritis In vitro and mouse studies identified a chemokine-targeting single-chain variable fragment (scFv)-based fusion protein that could help treat arthritis. Screening of a scFv library for binding to various human and mouse chemokines, engineering of...
11:07 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Patient sample and mouse experiments suggest that inhibiting CEBPB could help treat AD. In postmortem brain tissue samples from patients, levels of CEBPB were higher than in samples from unaffected subjects....
11:06 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Ovarian cancer Mouse studies suggest nanoparticles loaded with an ADORA2A antagonist and conjugated to CAR T cells could help treat ovarian cancer. The conjugate consists of cross-linked multilamellar liposomal nanoparticles loaded with a tool compound...
11:06 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Tuberculosis Mouse studies suggest a fusion protein-based vaccine plus a STING-activating cyclic dinucleotide (CDN) adjuvant could help prevent tuberculosis (TB). The fusion protein consists of five Mycobacterium tuberculosis antigens: fbpB, esxA, hrp1, rpfD and Rv1733c....
11:06 AM, May 15, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Retinitis Mouse studies suggest promoting expression of the proteasome subunits PSME1 or PSMD11 could help treat retinitis pigmentosa. In a mouse model of the disease, overexpression of PSME1 or PSMD11 increased photoreceptor survival and light...
1:02 PM, May 09, 2018  |  BC Innovations | Distillery Therapeutics

Cardiovascular; pulmonary

INDICATION: Myocardial infarction (MI); acute lung injury Patient sample and mouse studies suggest inhibiting CAMP could help treat MI and acute lung injury (ALI). In thrombus samples from MI patients, CAMP was highly expressed, and in...

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