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    E.g., 2018-11-15

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9185 items
12:45 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer, pancreatic cancer Patient sample and mouse studies suggest combining DNA-PK inhibitors with the oncolytic alphavirus M1 could help treat colorectal and pancreatic cancers. In colorectal tumor cells from patients, a DNA-PK inhibitor...
12:44 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Clostridium In vitro and mouse studies identified an inhibitor of C. difficile TcdB that could help treat C. difficile infection (CDI). Chemical synthesis and in vitro testing of hexakisphosphate analogs of inositol yielded a compound...
12:44 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Neurology In vitro, cell culture and mouse studies identified a PANK3 activator that could help treat pantothenate kinase-associated neurodegeneration (PKAN), which is caused by PANK2 deficiency and leads to low Coenzyme A levels in neuronal...
12:44 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Ophthalmic disease

INDICATION: Retinitis Patient sample studies suggest CRISPR-mediated editing of PRPF31 could help treat retinitis pigmentosa caused by a loss-of-function point mutation in the gene. In retinal pigment epithelium cells and photoreceptors of retinal organoids derived from...
12:43 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Adenocarcinoma Mouse studies suggest dual inhibition of MCL1 and MEK could help treat KRAS-mutant adenocarcinoma. In seven patient-derived xenograft (PDX) mouse models of KRAS-mutant adenocarcinoma, the MCL1 inhibitor AMG 176 plus the MEK inhibitor...
1:31 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Pancreatic cancer Patient sample, cell culture and mouse studies suggest inhibiting PIN1 could help treat pancreatic ductal adenocarcinoma (PDAC). In patients, PIN1 levels were higher in tumor samples than in adjacent normal tissue samples and...
1:30 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Other

INDICATION: Poisoning Mouse studies suggest a topical pyridine-2-aldoxime-based gel could help treat pesticide poisoning. The gel contains pyridine-2-aldoxime, which reverses binding and inactivation of AChE by pesticides, linked via an acetamide bridge to chitosan to functionalize...
1:30 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Cognitive dysfunction Mouse studies suggest inhibiting ACE could help treat lupus-associated cognitive dysfunction. In hippocampal tissue samples from a mouse model of the indication, ACE expression was higher than in samples from normal mice. Also...
1:29 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer In silico, cell culture and mouse studies suggest digoxin could help treat group 3 or 4 medulloblastoma. In silico screening of 1,309 FDA-approved small molecule drugs for compounds predicted to modulate highly active...
1:28 PM, Oct 31, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Cell culture studies identified an oligomer macrocycle-based inhibitor of the β-catenin-TCF4 interaction that could help treat prostate cancer. Chemical synthesis of oligomer macrocycles designed to inhibit the interaction between TCF4 and β-catenin, and...

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