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    E.g., 2018-09-22

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9064 items
12:32 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Encephalopathy Patient sample and mouse studies suggest inhibiting the JAK/STAT1 pathway, the interaction between MCP-1 and CCR2, or phagocyte activation could help treat Rasmussen encephalitis. In postmortem brain samples from patients, levels of phosphorylated STAT1...
12:32 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Pulmonary

INDICATION: Acute lung injury Mouse studies suggest inhibiting ZMPSTE24 with Kaletra lopinavir/ritonavir could help treat acute lung injury (ALI). In a mouse model of ventilator-induced ALI, systemic ZMPSTE24 knockout decreased markers of injury and increased oxygenation...
12:32 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/metabolic

INDICATION: Metabolic Mouse studies suggest ASL gene therapy could help treat argininosuccinic aciduria, which is caused by ASL mutations. In a mouse model of the disease, an adeno-associated viral (AAV) serotype 8 (AAV8) vector encoding ASL...
12:32 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Dengue fever Cell culture and rat studies identified an indole-based compound that could help treat dengue fever. Chemical synthesis and testing of indole analogs in monkey kidney cell-based assays yielded four compounds that inhibited replication...
12:31 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma; colorectal cancer Cell culture and mouse studies suggest MLKL mRNA plus electroporation could help treat melanoma and colorectal cancer. In a mouse melanoma cell line and three human melanoma cell lines, transfection with MLKL...
12:31 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies suggest inhibiting the USP5-CACNA1H interaction could help treat postsurgical pain. In a mouse model of incisional pain, shRNA targeting of USP5 or systemic knockout of CACNA1H decreased mechanical allodynia compared with vehicle...
12:30 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Mouse, rabbit and ferret studies suggest vaccines based on modified HA mRNA could help prevent infection by multiple strains of influenza A virus. The two vaccines consist of mRNA encoding HA from...
12:30 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Hematology

INDICATION: Bleeding Cell culture and mouse studies suggest inhibiting STAB2 could help treat von Willebrand disease, which is caused by deficiencies in the Factor VIII carrier vWF. In a mouse model of von Willebrand disease infused...
12:30 PM, Sep 10, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lung cancer Patient sample and mouse studies suggest promoting the expression of KIF16B, SELENOW and TESK2 could help prevent brain metastasis in lung cancer. In patients, low expression of KIF16B, SELENOW and TESK2 in primary...
10:55 AM, Aug 29, 2018  |  BC Innovations | Distillery Therapeutics

Inflammation

INDICATION: Inflammation Cell culture, mouse, rat and dog studies identified a RORγT inverse agonist that could help treat inflammation. Chemical synthesis and screening of a subset of Pfizer Inc.’s small compound library in a HEK-cell based...

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