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    E.g., 2018-07-15

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8922 items
10:52 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Staphylococcus; Streptococcus Cell culture studies identified a novel class of antimicrobial peptides that could help treat methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae infections. Testing of extracts of Microbacterium arborescens in bacterial cultures yielded multiple...
10:52 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Mouse studies suggest transferrin-conjugated liposomal nanoparticles loaded with temozolomide and an inhibitor of BET bromodomain proteins could help treat glioma. The liposomal nanoparticles contain distearoylglycerophosphoethanolamine (DSPE) conjugated to polyethylene glycol (PEG) and...
10:50 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Melanoma Patient sample, cell culture and mouse studies suggest inhibiting ELP3 or CTU2 could help treat drug-resistant BRAF-mutant melanoma. In tumor samples from melanoma patients, high expression of genes regulating post-transcriptional tRNA modification, including ELP3...
10:50 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Obesity Mouse studies suggest inhibiting IDO could help treat obesity. In a mouse model of high-fat diet-induced obesity, systemic IDO knockout decreased white adipose tissue (WAT), liver and body weights, lipid levels in the liver...
10:50 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain In vitro and mouse studies identified triazole sulfonamide-based Nav1.7 inhibitors that could help treat pain. Chemical synthesis of triazole sulfonamide-analogs and screening in cell-based binding assays yielded three compounds that bound human Nav1.7 with...
10:49 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Staphylococcus Cell culture studies identified three cadmium-based supramolecule coordination complexes (SCCs) that could help treat methicillin-resistant Staphylococcus aureus (MRSA) infection. The three SCCs consist of hexagonal-shaped rings that incorporate 12, 18 or 24 cadmium (II)-terpyridine...
10:49 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies suggest PENK-derived peptides alone or in combination with morphine could help treat pain. In a mouse model of heat-induced pain, intrathecal injection of BAM22, an endogenous PENK-derived peptide, decreased pain-like behaviors compared...
10:49 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies identified a benzopyran-based dual ESR1/ESR2 inhibitor and selective estrogen receptor down-regulator (SERD) that could help treat hormone therapy-resistant breast cancer. Chemical synthesis and testing in cell-based assays of...
10:48 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Meningitis Cell culture, mouse and rat studies suggest inhibiting CNTNAP1-dependent bacterial invasion could help treat meningitis caused by E. coli infection. In an E. coli invasion assay in a human brain microvascular endothelial cell line,...
10:48 AM, Jun 28, 2018  |  BC Innovations | Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Patient sample and mouse studies suggest inhibiting CASP1 could help treat MS. In patient postmortem brain tissue samples, levels of CASP1 were higher than in samples from unaffected subjects. In the experimental...

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