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    E.g., 2018-06-27
    E.g., 2018-06-27

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8837 items
11:21 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Patient sam/ple and cell culture studies suggest inhibiting DEPTOR could help treat colorectal cancer. In samples of colorectal tumors and the surrounding mucosa from patients, DEPTOR expression was higher than in normal colon...
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Transplant

INDICATION: Graft-versus-host disease (GvHD) Mouse studies suggest inhibiting DOT1L or overexpressing DUSP6 could help treat GvHD associated with T cell therapies. In a mouse model of xenogeneic T cell-associated GvHD, adoptive transfer of human CD8+...
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: HIV/AIDS Patient sample and cell culture studies identified three broadly neutralizing antibodies (bNAbs) against HIV gp120 that could help treat the infection. Screening of neutralizing antibodies against HIV gp120 isolated from a patient with natural...
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Patient sample, cell culture and mouse studies suggest promoting SPHK1 expression could help treat AD. In postmortem brain tissue samples from AD patients, neuron levels of SPHK1 were lower than in...
11:19 AM, May 23, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Lung Cancer Patient sample, cell culture and mouse studies suggest promoting expression of the long non-coding RNA (lncRNA) LINC00472 could help treat lung cancer. In patient samples, levels of LINC00472 were higher in tumors than...
10:56 AM, May 16, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Rett syndrome Patient sample and mouse studies suggest inhibiting GSK3B could help treat Rett syndrome. In postmortem cerebellum tissue samples from Rett syndrome patients, levels of GSK3B were higher than in samples from unaffected subjects....
10:51 AM, May 16, 2018  |  BC Innovations | Distillery Therapeutics

Pulmonary

INDICATION: Cystic fibrosis (CF) Cell culture studies identified a phenylbenzimidamide-based RNF5 inhibitor that could help treat CF in patients harboring the ΔF508 loss-of-function mutation in CFTR. In silico screening of a small molecule library for...
10:50 AM, May 16, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Respiratory syncytial virus (RSV); viral infection Patient sample and mouse studies suggest inhibiting PTGDR2 or agonizing PTGDR1 could help treat RSV and other viral infections. In nasal secretions from respiratory syncytial virus (RSV)-infected infants with...
10:50 AM, May 16, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) In vitro and mouse studies suggest a peptide-based agent that captures Aβ42 and induces autophagy could help treat AD. The “nanosweeper” agent consists of a PEGylated GKLVFF peptide that binds Aβ42 linked...
10:50 AM, May 16, 2018  |  BC Innovations | Distillery Therapeutics

Hematology

INDICATION: Hemophilia Mouse studies suggest transplantation of hepatocytes or Factor IX-expressing hepatocyte-like cells could help treat hemophilia B, which is caused by Factor IX mutations. The hepatocyte-like cells were generated from induced pluripotent stem (iPS)...

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