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    E.g., 2018-11-17

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9185 items
3:56 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Diabetes; obesity Patient sample, cell culture and mouse studies suggest inhibiting FXR with glycoursodeoxycholic acid could help treat obesity and obesity-related diabetes. In Type II diabetes patients receiving the generic diabetes drug metformin, serum and...
3:56 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics

Gastrointestinal

INDICATION: Colitis Mouse studies suggest exosome-like nanoparticles (ELNs) from the ginger plant or ginger-based nanovesicles loaded with ELN microRNA (miRNA) could help treat colitis. In a mouse model of colitis, ELNs derived from ginger or artificial...
1:20 PM, Nov 09, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer; cancer In vitro, cell culture and mouse studies identified a CDK9 inhibitor that could help treat colorectal and other cancers. Screening of a natural product library followed by chemical synthesis and in vitro...
12:48 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Brain cancer Patient sample, cell culture and mouse studies suggest inhibiting PRMT2 could help treat glioblastoma multiforme (GBM). In GBM patients, high tumor levels of PRMT2 were associated with poor survival. In two human GBM...
12:48 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Respiratory syncytial virus (RSV) Cell culture, mouse and rat studies identified an RSV F protein inhibitor that could help treat RSV infection. Optimization and testing in HeLa cell-based assays of a previously reported quinoline-based compound...
12:47 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Influenza virus Cell culture and mouse studies suggest a quadspecific antibody against influenza A and influenza B HA epitopes could help prevent infection by multiple strains of influenza A and influenza B viruses. The...
12:46 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Renal cancer Patient sample and mouse studies suggest promoting expression of IRF9 and STAT2 could help treat clear cell renal cell carcinoma (ccRCC). In patients, low levels of IRF9 in tumor samples were associated with...
12:46 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

INDICATION: Parkinson’s disease Patient sample, mouse and rat studies identified an NLRP3 inhibitor that could help treat PD. In patient postmortem brain tissue samples, levels of NLRP3 in the substantia nigra were higher than in...
12:46 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Liver cancer In silico, in vitro, cell culture and mouse studies identified a positive allosteric modulator (PAM) of SIRT6 that could help treat hepatocellular carcinoma (HCC). In silico screening of a small molecule library for...
12:45 PM, Nov 06, 2018  |  BC Innovations | Distillery Therapeutics

Infectious disease

INDICATION: Clostridium Cell culture studies suggest the tryptophan analogs 1-acetyl-β-carboline and turbomycin A could help treat Clostridium difficile infection (CDI). In C. difficile culture, the bacterial and fungal metabolite 1-acetyl-β-carboline and the antibiotic turbomycin A inhibited...

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