BioCentury

Inhibiting the EIF4G1-EIF4E interaction to treat autism

December 19, 2019 9:59 PM UTC

INDICATION: Autism

Disrupting the EIF4G1-EIF4E interaction could treat autism, a disorder characterized by social deficits and associated with increased dendritic spine densities and mutations in the E3 ligase complex component CUL3. In a CUL3-deficient mouse model of autism, a tool compound inhibitor of the EIF4G1-EIF4E interaction reduced social deficits and dendritic spine density. Next steps include testing the EIF4G1-EIF4E inhibitor in other models of autism...