Ketorolac and resolvins to prevent cancer recurrence

INDICATION: Cancer, lung cancer, lymphoma, melanoma, colorectal cancer

The generic COX inhibitor ketorolac and/or the resolvins RvD2, RvD3 and RvD4 could help prevent cancer recurrence due to chemotherapy- or surgery-induced inflammation. In mice with dormant Lewis lung carcinoma (LLC), lymphoma, melanoma and colon cancer, pretreatment with ketorolac decreased tumor growth after abdominal surgery or chemotherapy. In a mouse model of LLC with surgical resection of primary tumors, pretreatment with ketorolac, RvD2, RvD3 or RvD4 improved survival and reduced the number of lung micrometastases. Pretreatment with a combination of ketorolac and RvD2 increased survival compared with either agent alone. ...