Herb-derived flavonoid identified as potential TNBC treatment

INDICATION: Breast cancer

The natural product wogonoside, a SMO inhibitor, could help treat triple-negative breast cancer (TNBC), a new indication for SMO inhibition. Wogonoside is a flavonoid found in the herb Scutellaria baicalensis and was identified in an in silico screen of a library of natural products that bound one of 150 target proteins implicated in TNBC. In vitro binding assays showed the compound's target is SMO, and cell-based assays suggested it promotes ubiquitination-dependent SMO degradation. In a xenograft mouse model of TNBC, the compound decreased tumor weight by 55%...