PDE-1 inhibition could treat heart failure

INDICATION: Heart failure

Mouse studies suggest PDE-1 inhibitors could help treat a subtype of heart failure. In a mouse model of cardiac proteinopathy-induced heart failure with preserved ejection fraction, a tool compound PDE-1 inhibitor increased survival and three markers of left ventricular function -- end-diastolic volume, stroke volume and cardiac output -- compared with vehicle. Next steps could include testing other PDE-1 inhibitors in the model...