7:20 AM
May 14, 2019
 |  BC Innovations  |  Distillery Therapeutics

TRPC6 inhibitor for cardiac and renal fibrosis

DISEASE CATEGORY: Cardiovascular; renal

INDICATION: Cardiovascular; renal

Cell culture and mouse studies identified a trifluoromethylphenyl-based TRPC6 inhibitor that could help treat cardiac and renal fibrosis. High throughput screening of a small molecule library in cell-based activity assays, followed by optimization of top hits, yielded a trifluoromethylphenyl-based compound...

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