ADORA2A identified as a thrombosis target

INDICATION: Thrombosis

Cell culture and mouse studies suggest agonizing ADORA2A could help treat thrombosis. In primary human and mouse neutrophils treated with IgG from patients with antiphospholipid syndrome (APS), which is associated with thrombosis, a tool compound ADORA2A agonist decreased prothrombotic neutrophil extracellular trap (NET) levels compared with no treatment. In a mouse model of thrombosis and in the APS IgG-treated model, the ADORA2A agonist decreased thrombus incidence, weight and size. In another mouse model of thrombosis treated with APS patient IgG, the inhibitor decreased thrombus incidence, weight and size. Next steps could include testing other ADORA2A agonists in models of thrombosis...