ALK2 inhibition for diffuse intrinsic pontine glioma

INDICATION: Brain cancer

Cell culture and mouse studies suggest inhibiting ALK2 could help treat diffuse intrinsic pontine glioma (DIPG) in patients harboring activating ALK2 mutations. In tumorspheres derived from an ALK2-mutant mouse model of DIPG, a tool compound ALK2 inhibitor decreased proliferation and cell survival compared with vehicle. In two ALK2-mutant human DIPG cell lines, the ALK2 inhibitor decreased proliferation. In a mouse model of ALK2-mutant DIPG, the ALK2 inhibitor increased survival. Next steps by Keros Therapeutics Inc. could include optimizing and testing the ALK2 inhibitor in models of ALK2-mutant DIPG...