BioCentury
ARTICLE | Distillery Therapeutics

Infectious disease

February 28, 2019 1:29 AM UTC

Mouse studies suggest inhibiting CMA1 could help treat Japanese encephalitis (JE). In mice non-lethally infected with JE virus, serum levels of a mouse homolog of CMA1 were higher after infection with JE virus than pre-infection baselines. In mice lethally infected with JE virus, a tool compound CMA1 inhibitor decreased viral load in the brain and increased survival, grip strength and body weight compared with vehicle. Next steps include seeking partners for clinical testing of CMA1 inhibitors in JE...

BCIQ Company Profiles

Duke-NUS Medical School

BCIQ Target Profiles

Chymase 1 mast cell (CMA1)