Neurology
Mouse studies suggest depleting senescent cells could help treat obesity-induced anxiety. In a transgenic mouse model of obesity expressing the senescence marker human CDKN2A, a tool compound that depletes CDKN2A-positive cells decreased anxiety-like behaviors and blood levels of inflammatory cytokines compared with vehicle. In a genetic mouse model of obesity, a combination of the senolytic agents Sprycel dasatinib and quercetin decreased anxiety-like behaviors and blood levels of inflammatory cytokines. Next steps could include testing the Sprycel/quercetin combination in larger animal models of obesity-induced anxiety...
BCIQ Target Profiles
Cyclin dependent kinase inhibitor 2A (CDKN2A) (INK4a) (ARF) (p16INK4a)