4:25 PM
 | 
Oct 03, 2018
 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease; inflammation

INDICATION: Rheumatoid arthritis (RA); allergy

In vitro, mouse, rat and dog studies identified an aminotriazine-based Btk inhibitor that could help treat RA and allergy. Chemical synthesis, in vitro testing in activity assays and optimization of a series of previously reported pyrimidine analogs yielded an aminotriazine-based compound that inhibited activated and unactivated conformations of Btk with...

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