BioCentury
ARTICLE | Distillery Therapeutics

Dermatology

July 17, 2018 5:33 PM UTC

Mouse studies suggest a laminin peptide-antioxidant conjugate could help treat diabetic foot ulcers. The conjugate consists of a 12-mer peptide derived from LAMA5, which interacts with CD49C/CD29 and other integrins to promote epithelial cell migration, conjugated via click chemistry to the thermoresponsive antioxidant macromolecule poly(polyethylene glycol cocitric acid-co-N-isopropylacrylamide) (PPCN). In a diabetic mouse model with dorsal dermal ulcers, the conjugate increased the rate of wound closure and re-epithelialization compared with the laminin peptide alone, PPCN alone or PPCN conjugated to a fibronectin-binding peptide. Also in the model, the conjugate increased the rate of wound closure compared with Promogran Prisma. Next steps could include testing the conjugate in a large animal model of wound healing...

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