1:01 PM
May 09, 2018
 |  BC Innovations  |  Distillery Therapeutics

Renal; cardiovascular; hepatic

INDICATION: Renal failure; heart failure; liver failure

Mouse studies suggest inhibiting YY1 or its co-repressor FKBP12 could help treat chronic renal, heart and liver failure. In a mouse model of urethral obstruction-induced chronic renal failure, a tool compound FKBP12 inhibitor or guanidine dendrimer-linked morpholino oligomers targeting FKBP12 or YY1 decreased...

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