BioCentury
ARTICLE | Distillery Therapeutics

Cancer

May 9, 2018 3:24 PM UTC

Patient sample, cell culture and chicken embryo studies suggest inhibiting FZD8 could help treat prostate cancer. In patient samples, levels of FZD8 were higher in tumors than in adjacent normal prostate tissue. In two human prostate cancer cell lines, an siRNA targeting FZD8 decreased migration and invasiveness compared with a non-specific siRNA. In one of the cell lines, two tool compound FZD8 inhibitors decreased migration compared with vehicle. The FZD8-targeting siRNA decreased tumor cell invasiveness in two human prostate cancer organoids and decreased tumor growth in a xenograft chicken embryo model of prostate cancer. Next steps could include identifying and testing FZD8 inhibitors in models of prostate cancer...