BioCentury
ARTICLE | Distillery Therapeutics

Endocrine/metabolic

May 3, 2018 4:18 PM UTC

Mouse studies suggest KHK inhibitors could help treat hereditary fructose intolerance. In a mouse model of hereditary fructose intolerance, systemic KHK knockout decreased hypoglycemia, fibrosis and inflammation in the liver compared with normal KHK expression, and a tool compound KHK inhibitor decreased hypoglycemia compared with vehicle. Next steps could include testing other KHK inhibitors in the model...

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