4:23 PM
 | 
Mar 27, 2018
 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Multiple myeloma (MM)

Patient sample and mouse studies suggest inhibiting IL-18 or NLRP1 could help treat MM. In patient samples, high bone marrow plasma levels of IL-18 correlated with poor overall survival. In two mouse models of MM, systemic knockout of IL-18 or NLRP1 increased survival and decreased numbers of malignant plasma cells in the bone marrow compared with normal...

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