BioCentury
ARTICLE | Distillery Therapeutics

Cancer

March 7, 2018 7:11 PM UTC

Mouse studies suggest inhibiting FACT (facilitates chromatin transcription), a heterodimer consisting of SSRP1 and SUPT16H subunits, in combination with chemotherapy could help treat small cell lung cancer (SCLC). In three mouse models of SCLC, the FACT inhibitor CBL0137 plus the generic chemotherapy cisplatin decreased tumor growth compared with either compound alone or vehicle. Next steps could include testing the combination of FACT inhibition and chemotherapy in additional models of SCLC...

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