11:35 AM
 | 
Dec 05, 2017
 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Pancreatic cancer; melanoma

Cell culture and mouse studies suggest inhibiting MHCI, MHCI components or the macrophage MHC1 binding partner LILRB1 could help treat pancreatic cancer and melanoma. In co-culture of human pancreatic neuroendocrine tumor cell lines and macrophages, a combination of antibodies against CD47 and LILRB1 increased cancer cell phagocytosis compared with the anti-LILRB1 antibody alone. In a xenograft mouse model...

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