Cardiovascular

Patient sample and mouse studies suggest inhibiting CAMK2G could help treat atherosclerosis. In arterial plaque-associated macrophages from patients with carotid artery stenosis, levels of activated CAMK2G were higher in patients with stroke symptoms than in patients without the symptoms. In a mouse model of atherosclerosis, knockout of CAMK2G in myeloid cells decreased necrotic core area in plaques and increased fibrous cap thickness compared with normal expression. Next steps could include identifying and testing CAMK2G inhibitors in models of atherosclerosis...