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11:36 AM
 | 
Aug 09, 2017
 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Pain

Mouse studies suggest inhibiting the MKNK1-MKNK2-eIF4E axis could help treat pain. In a mouse model of inflammatory pain, knock-in of an elF4E variant that cannot be phosphorylated by MKNK1 or MKNK2 decreased mechanical hyperalgesia, mechanical allodynia and thermal allodynia compared with wild-type eIF4E expression. In a mouse model of...

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