10:06 AM
Mar 15, 2017
 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Chikungunya virus

Mouse studies suggest Gilenya fingolimod, Orencia abatacept and Xeljanz tofacitinib could help treat Chikungunya infection. Testing of a total of 11 drugs in mouse models of Chikungunya infection by two independent groups identified three compounds -- the S1P receptor antagonist Gilenya, the CD80/CD86 inhibitor Orencia and the JAK-1/JAK-3 inhibitor Xeljanz -- that alleviated infection-associated joint pathology. In one mouse model, Gilenya decreased joint inflammation, joint vascular...

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