Cardiovascular

Mouse and rat studies suggest inhibiting Factor XI could help treat arterial hypertension and consequent tissue damage. In a mouse model of arterial hypertension, an antisense oligonucleotide targeting Factor XI decreased blood pressure and vascular inflammation compared with a scrambled oligo. In a rat model of chronic kidney disease (CKD)-induced arterial hypertension, the oligonucleotide decreased blood pressure and kidney injury. Next steps include investigating whether individuals with naturally low FXI levels are partially protected from high blood pressure or organ damage. ...