Infectious disease

Mouse studies suggest inhibiting JNK1 could help treat Candida albicans infection. In a mouse model of C. albicans infection, knockout of JNK1 or two JNK1 inhibitor tool compounds decreased fungal burden and inflammation in the kidneys and increased survival compared with normal JNK1 expression or vehicle. Next steps include optimizing JNK1 inhibitors and testing in animal models of fungal infection...