Therapeutics: prepronociceptin (PNOC; NOP); μ opioid receptor (MOR; OPRM1)

Monkey studies suggest a dual MOR/PNOC agonist could help treat pain. In monkey models of thermal nociception and allodynia, a subcutaneous 0.01 mg/kg dose of an orvinol-based MOR/PNOC agonist decreas...