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Sep 22, 2016
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Aldehyde dehydrogenase 1 family member A1 (ALDH1A1); cytochrome P450 26A1 (CYP26A1; CP26)

Cancer

INDICATION: Colorectal cancer

Patient sample and mouse studies suggest enhancing all-trans retinoic acid (ATRA) levels could help treat colorectal cancer. In tumor samples from colorectal cancer patients, levels of ALDH1A1 - which participates in the biosynthesis of ATRA - were lower, and levels of CYP26A1- which catabolizes ATRA...

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