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 | 
Sep 15, 2016
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Activator protein-1 (AP-1; JUN); CDK5 regulatory subunit associated protein 1 (CDK5RAP1)

Endocrine/metabolic disease

INDICATION: Diabetes

Cell culture and mouse studies suggest AP-1 inhibitors could help treat Type II diabetes involving CDK5RAP1 mutations. In human pancreatic β cells generated from induced pluripotent stem (iPS) cells harboring mutant CDK5RAP1, an AP-1...

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