BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Metabotropic glutamate receptor subtype 1 (mGluR1; GRM1); SH3 and multiple ankyrin repeat domains 3 (SHANK3; PROSAP2; SPANK-2)

June 9, 2016 7:00 AM UTC

Mouse studies suggest positive allosteric modulators (PAMs) of mGluR1 could help treat autism spectrum disorders caused by SHANK3 haploinsufficiency. In a mouse model of SHANK3-deficient autism, an mG...