Therapeutics: P. falciparum dihydroorotate dehydrogenase (PfDHODH); P. vivax dihydroorotate dehydrogenase (PvDHODH)

In vitro and mouse studies identified triazolopyrimidine-based inhibitors of PfDHODH and PvDHODH that could help treat malaria. Chemical synthesis and in vitro testing of triazolopyrimidine analogs id...