12:00 AM
May 05, 2016
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: β-catenin (CTNNB1); wingless-type MMTV integration site family member 3A (WNT3A); 7-dehydrocholesterol reductase (DHCR7); glycogen synthase kinase


INDICATION: Genetic disorders

In vitro studies suggest activating Wnt/CTNNB1 signaling could help treat microcephaly associated with Smith-Lemli-Opitz syndrome, a developmental disorder caused by DHCR7 mutations. In patient-derived induced pluripotent stem (iPS) cells, levels of Wnt/CTNNB1 pathway...

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