Therapeutics: Nuclear factor of activated T cells cytoplasmic calcineurin-dependent 3 (NFATc3; NFAT4); protein phosphatase 3 regulatory subunit B α (PPP3R1)

Patient sample and mouse studies suggest inhibiting NFATc3 or PPP3R1 could help treat colorectal cancer (CRC). In CRC patients, NFATc3 nuclear activity in tumor cells correlated with poor survival and...