Therapeutics: κ opioid receptor (KOR; OPRK1); µ opioid receptor (MOR; OPRM1); opioid receptor δ1 (OPRD1; DOR); prepronociceptin (PNOC; NOP)

Neurology

INDICATION: Pain; diabetic neuropathy

In vitro, mouse and rat studies identified two agonists of KOR, MOR and OPRD1 and antagonists of PNOC

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