BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Thymic stromal lymphopoietin (TSLP)

March 10, 2016 8:00 AM UTC

Mouse studies suggest promoting dermal expression of TSLP could help treat breast cancer. In a mouse model of breast cancer, transgenic expression of human TSLP in the skin decreased primary tumor growth and the number of lung metastases, and increased tumor infiltration of T helper type 2 (Th2) cells, time to tumor onset, and survival compared with no transgene expression. Also in the model, topical application of the TSLP inducer calcipotriol to the skin decreased tumor growth compared with vehicle. In a mouse model of pancreatic cancer, transgenic expression of human TSLP in the skin decreased tumor growth compared with no transgene expression. Next steps could include testing promotion of dermal TSLP expression in xenograft models of breast and pancreatic cancers...