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 | 
Jan 28, 2016
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NRF2); heme oxygenase decycling 1 (HMOX1; HO-1; Hsp32)

Inflammation

INDICATION: Inflammation

Cell culture and mouse studies identified two activators of the anti-inflammatory NFE2L2/HMOX1 pathway that could help treat inflammation. Chemical synthesis and hemoglobin-based assays of compounds linking diverse NFE2L2 inducers to cobalt-carbon monoxide complexes identified two compounds that released carbon monoxide - which promotes up-regulation of NFE2L2 -...

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