Therapeutics: Heat shock protein 70 (Hsp70)

Mouse studies suggest Hsp70 could help treat age-related cognitive dysfunction. In aged mice, intranasal administration of human Hsp70 for up to five months increased neuronal density in the hippocampus, spatial memory function and lifespan, and decreased anxiety, compared with vehicle or heat-inactivated Hsp70. Next steps could include enhancing the transport of Hsp70 into neurons...