12:00 AM
 | 
Oct 15, 2015
 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Sterol O-acyltransferase 2 (SOAT2; ACAT2)

Cardiovascular disease

INDICATION: Atherosclerosis; hypercholesterolemia

In vitro and mouse studies identified an SOAT2 inhibitor that could help treat atherosclerosis and hypercholesterolemia. Chemical synthesis and in vitro testing of pyripyropene A analogs yielded a compound that inhibited SOAT2 with an IC50 of...

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